In the current review article, the studies conducted to investigate the anti-inflammatory activity of Aquilaria species are compiled and summarized. Since inflammation is the underlying cause of many diseases, the encounter of effective and safe biomedical anti-inflammatory compounds has become the focus of recent researches. Aquilaria species were known to possess a wide spectrum of pharmacological activities, among which anti-inflammatory activity has been reported in many in vitro and in vivo studies. Chromones, sesquiterpenoids, flavonoids, benzophenones and phorbol esters were the major anti-inflammatory compounds isolated from Aquilaria species. The objective of this review paper is to extend researches on the anti-inflammatory activity of different parts of Aquilaria species and support their future use in natural pharmaceutical preparations for the treatment of inflammation-associated conditions.   ..

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Aquilaria malaccensis has been traditionally used to treat several medical disorders including inflammation. However, the traditional claims of this plant as an anti-inflammatory agent has not been substantially evaluated using modern scientific techniques. The main objective of this study was to evaluate the anti-inflammatory effect of Aquilaria malacensis leaf extract (ALEX-M) and potentiate its activity through nano-encapsulation. The extract-loaded nanocapsules were fabricated using water-in-oil-in-water (w/o/w) emulsion method and characterized via multiple techniques including DLS, TEM, FTIR, and TGA. The toxicity and the anti-inflammatory activity of ALEX-M and the extract-loaded nanocapsules (ALEX-M-PNCs) were evaluated in-vitro on RAW 264.7 macrophages and in-vivo on zebrafish embryos. The nanocapsules demonstrated spherical shape with mean particle diameter of 167.13 � 1.24 nm, narrow size distribution (PDI = 0.29 � 0.01), and high encapsulation efficiency (87.36 � 1.81.....

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