The objectives of this study are to synthesize novel chitosan-hydroxyapatite composites doped with strontium, magnesium and zinc via in situ co-precipitation method, to investigate the bioactivity, cytotoxicity and antimicrobial properties of the materials. Physicochemical properties of the products obtained were analysed by X-ray powder diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential thermal analysis (DTA), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). The calcium release from the samples in simulated body fluid (SBF) were measured using atomic absorption spectroscopy (AAS). The synthesized composite materials were subjected to bioactivity studies in SBF. In vitro cytotoxicity studies were performed on the novel composite materials obtained. Antimicrobial activity investigations against E. coli were carried out on all the composite samples. Characterization of the .....

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Chitosan-hydroxyapatite composite doped with strontium was synthesised via in situ co-precipitation method. Physicochemical properties of the composite obtained were analysed using X-ray diffraction (XRD), infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX) and Thermogravimetry with differential thermal analysis (DT-TGA). The synthesised composite was subjected to bioactivity studies in simulated body fluid (SBF). The calcium release from the sample in SBF was measured using atomic absorption spectroscopy (AAS). The physicochemical properties and bioactivity of the novel composite was compared with that of hydroxyapatite, strontium doped hydroxyapatite and chitosan hydroxyapatite. The in vitro bioactivity studies of the novel composite showed that it has a higher release of Ca2+ in the SBF compared to the other samples. The novel material was also found to induce more Ca2+ deposition after 28 days of immersion in.....

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