This phytochemical study is aimed to extract, isolate and identify alkaloids from Alseodaphne corneri leaves. The crude alkaloid was extracted by cold percolation followed by acid-base extraction until Mayer test showed negative result. Then, it was separated by conventional chromatographic methods using column chromatography and preparative thin layer chromatography. The structural elucidation of isolated alkaloids was then carried out by spectroscopic techniques; UV, IR, NMR and HRESIMS. The structures of the compounds were also determined by comparison with previous study. Isolation of alkaloids yielded one new benzylisoquinoline; (6,7- dimethoxyisoquinolinyl)-(2',5'-dihydroxy-4'-methoxyphenyl)-methanone 68, one bisbenylisoquinoline; obamegine 49, one oxoaporphines; atheroline 71, and five aporphine; isocorydine 48, N-methyllaurotetanine 51, laurotetanine 53, lirioferine 69 and norlirioferine 70. The benzylisoquinoline type alkaloid, lirioferine 69 and atheroline 71 were first repor.....

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The isolation and purification of the leaves extract of Alseodaphne corneri Kosterm yielded four alkaloids; norisocorydine 1, isocorydine 2, 2-norobamegine 3 and obamegine 4. This phytochemical study involves extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectroscopy (UV), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) including 1D-NMR (1H, 13C and DEPT), 2D-NMR (COSY, NOESY, HMQC/HSQC, and HMBC) and mass spectrometry (MS). The IC50 value of antiplasmodial activity for isocorydine 2 and obamegine 4 are 0.50 μmolL-1 and 0.14 μmolL-1 respectively...

5141 hits

A phytochemical study on the leaf extract of Alseodaphne corneri Kosterm involving extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectra (UV), infrared spectra (IR), nuclear magnetic resonance (NMR) and mass spectra (MS) was carried out. The isolation and purification from the leaves of Alseodaphne corneri Kosterm yielded two aporphines: norlirioferine and lirioferine...

5526 hits