This study aimed to identify the major allergens of two species of snails, Cerithidea obtusa (C. obtusa) and Pila polita (P. polita). C. obtusa and P. polita samples were obtained from Perak and Kelantan, respectively.Subsequently, the cross-reactive allergens between C. obtusa and P. polita with common local shellfish including Penaeus monodon (P. monodon), Loligo edulis (L. edulis) dan Scylla serrata (S. serrata) were identified. Proteins of C. obtusa, P. polita, P. monodon, L. edulis and S. serrata were extracted from their flesh. Protein profiles were determined by sodium dodecyl sulfatepolyacrylamide gel electrophoresis (SDS-PAGE). Major and cross-reactive allergens were then identified by immunoblotting and immunoblotting inhibition tests, respectively using sera from patients with allergy to C. obtusa, P. polita, P. monodon, L. edulis dan S. serrata. The major allergens of C. obtusa and P. polita were then identified by mass spectrometry analysis. Research findings showed that C.....

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