Chromolaena odorata has reported to have medicinal value due to the presence of active compounds which have antimicrobial and wound healing properties. Therefore, this study was carried out to formulate the antimicrobial cream from C. odorata extract used for wound healing treatment. The study aims to screen the secondary metabolites and determine C. odorata extract concentration for antimicrobial activity to be used in cream formulation. The leaves were extracted in 95% methanol and 95% ethanol for secondary metabolite screening and Gas Chromatography-Mass Spectrometry. Chromolaena odorata extract with a concentration of 5%, 10%, 15% and 20% was performed for antimicrobial activity tested on Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. The best of C. odorata extract concentration was used in six formulations of antimicrobial cream. The stability test was performed on all cream formulations. The methanolic extract .....

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