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Total records found : 1
Simplified search suggestions : Nur Farah Nadia Abd Karim
12024
Thesis
Optical, optomechanical and density functional theory modelling investigation of calixarene Langmuir-Blodgett thin film for drug encapsulation
Nur Farah Nadia Abd Karim
The research aim is to create a calixarene-based nanosensor targeting paraaminobenzoic acid (PABA) using Langmuir-Blodgett (LB) method. The properties of the LB film were assessed. The optical and optomechanical characteristics were examined with ultraviolet visible (UV-vis) spectroscopy and optical tweezers (OT). The host-guest binding energy was calculated using DFT method. Calix[4]arene (C4) and calix[8]arene (C8) solutions with concentration of 0.47 mM and 0.23 mM respectively, were prepared and different PABA concentrations (0.01 to 0.71 mM) was used to study the interactions. The thin films were optically analysed at wavelength of 250 to 400 nm. Microclusters with radii of 0.5-1.5 _m were optically trapped at various power density (0.23 to 2.49 MW/cm2). Complex_s binding energy were calculated using optimisation calculation. C4 and C8 monolayers effectively trapped PABA, resulting in 1:1 and 1:2 stoichiometry ratios. C8 was significantly more sensitive towards PABA, detecting eve.....

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