Mahanimbine, a prenylated carbazole found primarily in the Rutaceae family, has remarkable biological features such as anticancer, antidiabetic and antioxidant. Therefore, it is intriguing to tweak the mahanimbine structure with the aim of adding extra value to their activity. Three new derivatives were semi-synthesised by N-alkylation of naturally isolated mahanimbine using alkyl bromides, yielding N-butylmahanimbine, N-(3-methylbutyl) mahanimbine, and N-benzylmahanimbine. The structures of N-alkylated mahanimbines were elucidated using different spectroscopic techniques (FTIR, GCMS, and NMR). Keywords: mahanimbine, alkylation, N-terminal, derivative, Murraya..

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