Context: Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective: To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization, and postprandial glucose metabolism. Design: 1) Acute, randomised, crossover design (Acute Study); 2) 6-week, randomised, controlled design (Training Study). Setting: General community. Participants: Men with overweight/obesity (mean±SD, BMI: 30.2±3.5 kg?m-2 for Acute Study, 30.9±4.5 kg?m-2 for Training Study). Interventions: Moderate-intensity cycling performed before versus after mixedmacronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results: Acute Study - exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: -3.44±2.63% versus 1.44±4.18% area lipid staining, p < 0.01) and type II fibres .....

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