AbstractThe study aimed to investigate the chemical constituents from Polyalthia lateriflora,
Alphonsea elliptica and Alphonsea cylindrica as well as their cytotoxic, antioxidant and
xanthine oxidase inhibitory activities. These samples were collected from Peninsular
Malaysia and then extracted sequentially using hexane, dichloromethane and methanol.
The chemical compounds were isolated and purified by various chromatographic
techniques and their structures were elucidated via spectroscopic method especially
Nuclear Magnetic Resonance, Mass Spectrometry, Infrared, Ultraviolet and comparison
with literature. Cytotoxic activity was analysed on MCF-7 human breast cancer cells while
antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Study on
P. lateriflora has yielded six compounds which were lupeol, stigmasterol, Omethylmoschotaline,
atherospermidine, lysicamine and liriodenine. Meanwhile, five
compounds namely kinabaline, atherospermidine, liriodenine, N-met.....