Two new isoquinoline alkaloids, iraqiine (1) and kareemine (2), along with five known alkaloids, muniranine (3), kinabaline (4), O-methylmoschatoline (5), atherospermidine (6) and N-methylouregidione (7), were purified from the dichloromethane crude extract of Alphonsea cylindrica bark. The structures of these compounds were elucidated through extensive 1D and 2D NMR, IR and LC–MS studies and comparison with previously reported data. Compounds (1–5 and 7) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1, 3 and 4 showed the highest antioxidant activities with IC50 values of 48.77 ± 1.01, 44.51 ± 1.12 and 64.28 ± 0.93 μg/ml, respectively  ..

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The study aimed to investigate the chemical constituents from Polyalthia lateriflora, Alphonsea elliptica and Alphonsea cylindrica as well as their cytotoxic, antioxidant and xanthine oxidase inhibitory activities. These samples were collected from Peninsular Malaysia and then extracted sequentially using hexane, dichloromethane and methanol. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via spectroscopic method especially Nuclear Magnetic Resonance, Mass Spectrometry, Infrared, Ultraviolet and comparison with literature. Cytotoxic activity was analysed on MCF-7 human breast cancer cells while antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Study on P. lateriflora has yielded six compounds which were lupeol, stigmasterol, Omethylmoschotaline, atherospermidine, lysicamine and liriodenine. Meanwhile, five compounds namely kinabaline, atherospermidine, liriodenine, N-met.....

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