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UPSI Digital Repository (UDRep)
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| Total records found : 2 |
| Simplified search suggestions : Siti Mariam Mohd Nor |
| 1 | 2017 article | Synthesis of n-alkylated and n-acylated derivatives of girinimbine Mohd Nor Siti Mariam, Osman Fatin Nurul Atiqah, Ahmad Kartini, Nafiah Mohd Azlan, 3006 hits |
| 2 | 2021 article | Cytotoxicity effect of natural and synthetic girinimbines and their derivatives against human lung cancer cell lines A549 Siti Mariam Mohd Nor The present study was designed to evaluate the anticancer properties of girinimbine and its derivatives. Two different routes for the synthesis of girinimbine involving a two-step reaction or a one-pot reaction were studied. Girinimbine was synthesised through metal-catalysed heterocoupling, indole ring closure, ether formation, and Claisen cyclisation. Girinimbine derivatives were prepared by the semi-synthesis of isolated girinimbine from Murraya koenigii through alkylation or acylation reactions. Natural and synthetic girinimbines, five derivatives of N-substituted girinimbine, and three intermediates from the synthesis of girinimbine were evaluated for cytotoxicity activity against human lung cancer (A549) and normal lung (MRC-5) cell lines. The structures of all the synthesised compounds were confirmed by spectroscopic analysis and comparison with published data. The cytotoxicity assay showed that the natural girinimbine and nitrobiphenyl intermediate exhibited high toxicity (IC50..... 598 hits |