Leptin is known to increase glucose metabolism and energy expenditure while insulin increases glucose uptake into peripheral tissue. However, in obese and type 2 diabetes mellitus (T2DM) patients, high levels of both leptin and insulin are observed, indicating resistance to these two hormones in these individuals. It is unclear if elevated leptin levels are the cause of insulin resistance in these individuals. Physical exercise is known to be useful in the management of obesity and T2DM. It has been found that exercise can decrease bodyweight and increase glucose uptake in these individuals following exercise. This study aims to determine the effect of chronic leptin treatment and exercise on body weight, serum glucose and insulin levels of Sprague-Dawley rat. Eight-week old rats were treated with either intraperitoneal injection of normal saline (Control; n=8), or leptin (60 μg/kg body weight/day; Leptin; n=8), or leptin and exercise (60 μg/kg body weight/day plus running on a tread.....

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