The purpose of this study was to investigate the essential oil composition, phytochemicals, and antioxidant activity from the leaves of Piper crassipes. Essential oil was obtained from the leaves by hydrodistillation, and its chemical compositions was determined using gas chromatography (GC) and gas chromatography mass spectrometry (GC-MS). Soxhlet extraction was performed for the leaves part, followed by isolation of phytochemicals using silica gel column chromatography. The chemical structures of isolated compounds were determined using spectral analysis (Infrared Spectroscopy, Nuclear Magnetic Resonance Spectroscopy, and Mass Spectrometry) and comparison with literature data. Antioxidant activity was evaluated using the 2,2- diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and total phenolic content. Twenty-two compounds (97.8%) were identified in the leaf oil with chavibetol (59.8%), chavibetol acetate (10.4%), _-muurolene (5.4%), and germacrene D (4.6%) as major comp.....

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