AbstractThe increasing occurrences of youth unemployment and the associated vices led to the introduction of Marketing Trade subject, and other trade/entrepreneurship subjects, at senior secondary schools in Nigeria. Therefore, this study was carried out to assess the instructional strategies and students’ entrepreneurship empowerment through the acquisition of competences in Marketing Trade subject. The study raised and answered two related research questions and also formulated and tested one relevant research on the null hypothesis (H0). The descriptive survey research design was adopted for the study. The population for the study comprised 1367 students of Marketing Trade subject in the randomly selected public senior secondary schools under Education District IV of Lagos State, Nigeria. Using Taro Yamane’s sample size calculation method, the sample size was 309 respondents, but 308 was returned eventually. The research instrument used was structured questionnaire. The Cronbach Alpha c.....