AbstractSolanum hirtum (Solanaceae) has been used in traditional medicine to heal several illnesses, it’s worked as an antiseptic for sore throat and other diseases. The present study describes the phytochemical profiles, antibacterial, and antioxidant properties of S. hirtum fruits. The phytochemicals from the dried fruits were extracted using a maceration technique with methanol and the flash column chromatography with n-hexane, dichloromethane, and methanol was the selected means to fraction the extract. The phytochemical screening was implemented using standard chemical tests. The antibacterial and antioxidant activities were screened using the disc diffusion method, and analyzing the radical scavenging activity using 2,2´-diphenyl-1-picryhydrazyl (DPPH), respectively, whilst the total phenolic content was measured using the Folin-Ciocalteu method. The phytochemical analysis results revealed the presence of terpenoids, steroids, phenols, flavonoids, and alkaloids. Antibacterial activity.....