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8 record(s) found

5
Abstract
This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4), muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10) and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3, 4, 5, 6, 8, 10 and 11 di.....
Article Published 2019 1240 hits Available
6
Abstract
Background: Obesity is one serious health condition that contributes to various chronic diseases. The inhibition of pancreatic lipase is a promising treatment for obesity. Objective: The present study was designed to investigate anti-porcine pancreatic lipase effect of isolated compounds from Aquilaria subintegra and its mechanism. Method: Compounds were isolated with serial column chromatography and their structure were identified using spectroscopic methods. Isolated compounds were tested for anti-lipase potential activity using colorimetric assay. The prediction of energy binding between isolated compounds and enzyme was described using YASARA software. Results: Four compounds were successfully isolated from the bark of A. subintegra, namely, 5-hydroxy-7,4’-dimethoxyflavone, luteolin-7,3’,4’-trimethyl ether, 5,3’-dihydroxy-7,4’-dimethoxyflavone and β-sitosterol. The results indicated that all compounds displayed promising pancreatic lipase inhibitory activity ranging b.....
Article Published 2019 972 hits Available
7
Abstract
A phytochemical study of dichloromethane extract of Alphonsea elliptica has led to the isolation of two compounds previously unreported from the species methyl syringate and isovanilic acid. Stigmasterol which has been previously reported was also isolated. The structures were determined by spectroscopic techniques and by comparison with data reported in the literature. The findings of this study will contribute to the chemotaxonomic and phylogenetic aspects of the Alphonsea sp. ? 2021 World Research Association. All rights reserved...
Article Published 2021 1219 hits Available
8
Abstract
Kajian ini dijalankan bagi melihat amalan sebenar sekolah menengah di daerah Kubang Pasu yang diberi taraf Pusat Tanggungjawab (PTj) dalam mengurus kewangan sekolah. Kajian ini juga dijalankan bagi mengenal pasti sumber kewangan yang diterima oleh pihak sekolah yang diberi taraf PTj. Di samping itu, kajian ini turut meninjau kebaikan serta keburukan pelaksanaan kewangan sekolah menengah bertaraf PTj dan seterusnya mengenal pasti keberkesanan pelaksanaan pemberian taraf PTj di peringkat sekolah. Kaedah penyelidikan adalah secara kualitatif dan data diperolehi melalui temu bual bersama lima orang responden dan disokong oleh data yang diperolehi melalui senarai semak. Dapatan kajian menunjukkan sumber kewangan sekolah terdiri daripada PCG, SUWA dan waran peruntukan kecil. Kajian juga menunjukkan sekolah kajian telah mematuhi semua prosedur dan tatacara pengurusan kewangan yang telah ditetapkan. Hasil kajian juga mendapati pemberian taraf PTj menjadikan urusan kewangan sekolah .....
Thesis Published 2013 680 hits Available

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