This study aims to develop modified multiwalled carbon nanotubes paste electrodes based on pyrazolone derivative ligand for detecting acetaminophen (APAP), dopamine (DOP), and ascorbic acid (AA). 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone (HPMBP) has been synthesized by mixing of 1-phenyl-3-methyl-5-pyrazolone (PMP) and benzoyl chloride. Second ligand, 1-phenyl-3-methyl-4-(2-fluorobenzoyl)-5-pyrazolone (HPMoFBP) and third ligand, 1-phenyl-3-methyl-4-(3-fluorobenzoyl)-5-pyrazolone (HPMmFBP) have been prepared by mixing of PMP with 2-fluorobenzoyl chloride and 3-fluorobenzoyl chloride separately. To produce the sensor, these ligands are mixed with multiwalled carbon nanotubes and placed in a Teflon tube. The carbon-13 nuclear magnetic resonance (13C NMR) spectrum of HPMBP exhibited chemical shift of 119.20 ppm and 132.01 ppm at the C2_ and C3_ position, respectively. The presence of the fluorine atom deshielded the C2_ of HPMoFBP and C3_ of HPMmFBP to 159.91 ppm and 160.99 ppm, respectivel.....

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