The aim  of this  study  was  to  improve  antimicrobial  properties  of fish  scales  hydroxyapatite/fish collagen (FsHA/FsCol) composites through infiltration of silver nanoparticles  into the matrix for antimicrobial bone filller substitute. In this sudy both hydroxyapatite and  collagen were extracted from fish scales using simple hydrothermal extraction method. Silver  nanoparticles (AgNPs) were synthesized from silver nitrate using microwave-assisted method in which  neems leaves extract was used as reducing agent while fish collagen as stabilizer. FsHA/FsCol/AgNPs  composites were prepared in a form of powders and beads using two different methods. Chemical and  physical properties of AgNPs and FsHA/FsCol/AgNPs composites were characterized using field  emmision scanning electron microscope with energy dispersive x-ray (FESEM-EDX), transmission   electron  microscopy  (TEM),  Fourier transform  infrared  spectroscopy (FTIR) and  x-ray  diffrac.....

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