AbstractThe high occurrence of mental health issues among adolescents in low-income countries is a significant public health concern with limited evidence-based treatment documentation. The study evaluated the effectiveness of psychoeducation as a viable treatment for psychological distress among in-school adolescents in low-Income setting. Using quasi-experimental pre-test post-test control group design, data were collected using a standardized self-report questionnaire (DASS-21) from 240 students in four co-educational secondary schools in Oyo-East Area Council of Oyo State, Nigeria. Forty-eight participants with a mean age (13.02; SD±1.97), scoring above the mean (M=30.6) were gender-matched and randomly placed into intervention and control groups, each comprising 24 participants. Results revealed that psychoeducation effectively reduced psychological distress symptoms in the experimental group after six weeks of exposure (t (22) = 5.11, p < 0.001). A significant mean difference in psychol.....