The impact of spatial heterogeneity on industrial outputs is a new important topic in economic geography. A considerable amount of research literature has accumulated, but the academic community lacks a systematic and comprehensive review and consensus on this topic. This study carried out research by mining the relevant classical literature. This investigation first combed the connotation of spatial heterogeneity, which is both corresponding to and related to spatial dependence. Theorists generally acknowledge that there is spatial heterogeneity in the process of industrial outputs. Then this study summarizes the logical basis, relationship coordination, measurement and other aspects of the effect of spatial heterogeneity on industrial outputs. In analyzing the impact of spatial heterogeneity on industrial outputs, we should not ignore the spatial dimension, but must also pay attention to the heterogeneity of individual enterprises. Industrial output analysis needs to be based on the .....

52 hits

Modern medicine and technology have enhanced the average life expectancy of a person, but this has not improved the quality of life for those who are getting older. Elderly persons struggle to take care of their fundamental requirements, and family members are unable to give them the attention they require. An online community based new method of communication and interaction for the elderly could be a solution to address the situation, however, there are difficulties observed with the elderly persons throughout the design stage. In order to address the unmet everyday needs of older adults, this study investigated the design methodology and design process for an online social interaction community (OnSocialCom). A conceptual model was proposed specifically for senior people who live alone and was based on social connectedness, social support models, structural Camberwell evaluation of need for the elderly theories, and 4W (What-Where-When-Who) models. Its application in the actual sett.....

55 hits

Playing mobile MOBA games has become a popular leisure activity among Malaysian youth. However, MOBA games are highly addictive and have negative impacts on adult development. Inadequate local studies investigated the risk factors of excessive MOBA gameplay. The present study examined the (1) predictive role of need frustration on Internet gaming disorder (IGD) and (2) mediating effect of gaming motives. A total of 398 mobile MOBA gamers aged 18 to 29 participated in this cross-sectional online survey study. The findings showed that need frustration positively predicted IGD. Social, escape, competition, coping, and skill motives were significant mediators for the association between need frustration and IGD. However, fantasy and recreation motives were not significant mediators. MOBA players who were frustrated while fulfilling their basic needs may succumb to uncontrollable gaming behavior. Therefore, future prevention and intervention programs should cultivate positive mental strengt.....

75 hits

Background: Meyerozyma guilliermondii is a prospective yeast that has extensively contributed to the biotechnology sector. In 2015, M. guilliermondii strain SO which was isolated from spoiled orange has successfully been developed as an inducer-free expression system and attained a significant impact in producing industrially important recombinant proteins. The species possesses high similarity to Candida albicans which may cause candidiasis. The industrial-benefiting M. guilliermondii strain SO has been underexplored for its virulence status. Thus, this study aimed to document the potential virulence factors through the comprehensive in silico analysis of M. guilliermondii strain SO genome. This analysis demonstrated the molecular characterization which could distinguish the pathogenicity status of M. guilliermondii. Results: The genome data were generated from Illumina HiSeq 4000 sequencing platform and assembled into 51 scaffolds successfully accumulating a genome size of 10.63 Mbp......

77 hits

Computer Numerical Control (CNC) systems are moving toward adopting the STEP-NC data interface model as their future standard. It has been developed for use in subtractive manufacturing with great success, but its use in additive manufacturing is still in the research and development stage. The incorporation of STEP-NC into the CNC system is still an open and present challenge. This article presents a method for making use of the STEP-NC data interface model for 3D printing. The method makes use of the CAD data of either the ISO10303 or ISO 14649 data interface model in part 21 of the physical file representation. A system is being developed to generate the tool paths necessary for 3D printing from STEP-NC part 21. It has been carried out on a 3D printer through the utilization of indirect and interpreted STEP-NC programming techniques. In order to carry out 3D printing operations, the system makes use of tools that are based on virtual component technology and are controlled by a part.....

59 hits

The Coronavirus disease 2019, or COVID-19, has shifted the medical paradigm from face-to-face to telehealth. Telehealth has become a vital resource to contain the virus spread and ensure the continued care of patients. In terms of preventing cardiovascular diseases, automating electrocardiogram (ECG) classification is a promising telehealth intervention. The healthcare service ensures that patient care is appropriate, comfortable, and accessible. Convolutional neural networks (CNNs) have demonstrated promising results in ECG categorization, which require high accuracy and short training time to ensure healthcare quality. This study proposes a one-dimensional-CNN (1D-CNN) arrhythmia classification based on the differential evolution (DE) algorithm to optimize the accuracy of ECG classification and training time. The performance of 1D-CNNs of different activation functions are optimized based on the standard DE algorithm. Finally, based on MIT-BIH and SCDH arrhythmia databases, the perfo.....

96 hits

Malignant transformations are dependent on an aberrant increase in tubulin and microtubule activities for cancer cell growth, migration, invasion and metastasis. The present work includes design and synthesis of a new series of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors. These derivatives harness lipophilicity, ease of synthesis and antiproliferative activity of lipidated 1,3-diaryl propenones and their cyclized derivatives. New compounds were synthesized from 4?-hydroxyacetophenone via O-alkylation, condensation with different aromatic aldehydes followed by cyclization with urea, thiourea or guanidine. Cyclization of 1,3-diaryl propenones into 4,6-diaryl pyrimidines increased their antiproliferative activity with the most potent derivative 19 achieving IC50 values at low micro molar concentration against two human cancer cell lines; MCF-7 (breast) and HepG-2 (liver). Compound 19 induced S-phase cell cycle arrest and a.....

68 hits

Introduction: Cancer is a major issue in medical science with increasing death cases every year worldwide. Therefore, searching for alternatives and nonorthodox methods of treatments with high efficiency, selectivity and less toxicity is the main goal in fighting cancer. Acetyl-11-keto-?-boswellic acid (AKBA), is a derivative pentacyclic triterpenoid that exhibited various biological activities with potential anti-tumoral agents. In this research, AKBA was utilized to examine the potential cytotoxic activity against MCF-7 cells in vitro and monitor the cellular and morphological changes with a prospective impact on apoptosis induction. Methods: The cytotoxic activity of AKBA was measured by 3(4,5dimethylthiazole- 2-yl)-2,5 diphyneltetrazolium bromide (MTT) assay. A dose-dependent inhibition in MCF-7 cell viability was detected. The clonogenicity of MCF-7 cells was significantly suppressed by AKBA increment in comparison with untreated cells. Result: Morphologically, exposure of MCF-7 c.....

58 hits

The optical absorption and emission properties of 20Li2O-xBi2O3-(78-x)TeO2-1Er2O3-1Ag glass system had been analyzed to investigate the hypersensitivity shift and its mechanism. According to the Covalent model, the hypersensitive shift indicated by the drop of F2 at x = 5 mol% can be attributed to charge transfer from O2 ligands to Er3+ ions meanwhile according to the Dielectric screening model, drop of F2 may due to Er3+ ions contraction. The dynamic coupling mechanism was used to explain hypersensitivity transition probabilities in non-centrosymmetric systems. The addition of Bi2O3 may modify the site symmetry of Er3+ ions and oxygen to a high asymmetry ?2, resulting in an asymmetrical electron distribution, thus increasing Er-O covalency, as shown by the maximum ?2 value at x = 5 mol%. The Er3+ ions site symmetry was investigated using Hamiltonian crystal field fitting in the frame of the D4 point symmetry model, which yielded maximum crystal field strength Nv at x = 5 mol%, indicat.....

118 hits

The iridium(III) complex, Ir(bFppy)2(pyim) (bFppy = 2-(2-butoxy-4-fluorophenyl)pyridine and pyim = 2-(1H-Imidazol-2-yl)pyridine) was excellently prepared between 2-(1H-Imidazol-2-yl)pyridine and chloro-bridged iridium(III) dimer via reflux reaction. Butoxy functional group and fluorine atom were added to the phenyl ring of 2-phenylpyridine at positions 2 and 4 respectively, as cyclometalating ligand. The Ir(bFppy)2(pyim) complex was characterized by spectroscopic methods: FTIR, NMR, LCMS and UVVis absorption. The presence of two sharp peaks at 1256 cm?1 and 1129 cm?1 due to ?(CO) was revealed by IR analysis. The bands appear in the range of 15941567 cm?1 owing to the C[dbnd]C and C[dbnd]N aromatic ring stretching vibrations of phenyl and pyridine. The 1H NMR spectrum showed signals in the range of ? 5.508.60 ppm corresponding to phenylpyridine and pyridylimidazole protons. In contrast, the proton signals in the range of ? 0.804.50 ppm, assignable to butyl substituent. The UVVis spectru.....

78 hits