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28 record(s) found

Isolation Of Stigmasterol from the leaves of Kopsia Singapurensis RIDL

Lee Yean Shan, Ahmad Kartini, Awang Khalijah, Tan Siow Ping, Nafiah Mohd Azlan,

Abstract

The isolation and purification of the leaves of Kopsia singapurensisRidl. (Apocynaceae) revealed the presence of steroids, terpenes, and alkaloids. Stigmasterol 1 was isolated from the hexane crude extract of the leaves of this species. This phytochemical study involves extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as IR, NMR including 1D-NMR (1H, 13C and DEPT), 2D-NMR (COSY, NOESY, HMQC/HSQC, and HMBC) and GCMS, involving also comparison with data from the literature..

Conference Item Published 2012 6405 hits Available

Chemical Constituent from Alstonia Spathulata BL. (Apocynaceae)

Tee Chuan Thing, Ahmad Kartini, Awang Khalijah, Tan Siow Ping, Nafiah Mohd Azlan,

Abstract

In Malaysia, Alstonia spathulataBl. is locally known as pulai basong which distribute in peat forest. The separations of the chemical components from hexane crude extract (bark) of Alstonia spathulata were carried out using different chromatographic techniques (column chromatography and thin layer chromatography). One compound were isolated and identified as lupeol acetate (1). This compound have never been reported and isolated from this species. The structures of this compound were elucidated based on the basis of detailed 1D-NMR (1H, 13C and DEPT) and 2DNMR (COSY, HSQC, HMBC) spectroscopic analysis. The data analysis was also compared with the literature...

Conference Item Published 2012 6168 hits Available

Isolation Of Boldine from Alseodaphne Peduncularis (Wall. Ex. Ness) Meissn (Lauraceae)

Mohammad Siti Nor Fadzilah, Nafiah Mohd Azlan, Ahmad Kartini,

Abstract

A phytochemical investigation of the bark of Alseodaphne peduncularis (Wall. Ex. Ness) Meissn (Lauraceae) has resulted in the isolation of a known aporphine alkaloid; boldine (1). The isolation and purification of the alkaloids were achieved using column chromatography (CC) and preparative thin layer chromatography (PTLC). The structural elucidation was performed by spectral methods mainly 1D and 2D NMR, IR, UV and MS, and in comparison with data from other literature...

Conference Item Published 2012 6417 hits Available

Extraction and isolation of alkaloids from the leaves of Alseodaphne corneri Kosterm

Nafiah Mohd Azlan, Khoo Jennie,Hui Chen, Mohammad Siti Nor Fadzilah, Awang Khalijah, A. Hadi A. Hamid, Ahmad Kartini,

Abstract

The isolation and purification of the leaves extract of Alseodaphne corneri Kosterm yielded four alkaloids; norisocorydine 1, isocorydine 2, 2-norobamegine 3 and obamegine 4. This phytochemical study involves extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectroscopy (UV), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) including 1D-NMR (1H, 13C and DEPT), 2D-NMR (COSY, NOESY, HMQC/HSQC, and HMBC) and mass spectrometry (MS). The IC50 value of antiplasmodial activity for isocorydine 2 and obamegine 4 are 0.50 μmolL-1 and 0.14 μmolL-1 respectively...

Article Published 2013 6775 hits Available

Hernagine type of Aporphine Alkaloids from Alseodaphne perakensis

Md Nazimuddin Mahfuzah, Husna Hasnan Muhammad Hafiz, Ahmad Kartini, Awang Khalijah, Nafiah Mohd Azlan,

Abstract

A phytochemical study of the stem bark of Alseodaphne perakensis (Lauraceae) had been carried out. The dichloromethane crude extract from stem bark of Alseodaphne perakensis (Lauraceae) yielded two hernagine type of aporphine alkaloids namely oxohernagine and N-methylhernagine. The isolation and purification of these alkaloids were achieved using Column Chromatography (CC) and Preparative Thin Layer Chromatography (PTLC) techniques. The structural elucidations were performed by spectral methods notably Nuclear Magnetic Resonance (NMR) Spectroscopy one-dimentional (1H, 13C and DEPT) and two-dimentional (COSY, HMQC/HSQC and HMBC)...

Article Published 2014 4138 hits Available

C23-Carbazole Alkaloids from the bark of Murraya koenigii (L.) Spreng

Tan Siow Ping, Nafiah Mohd Azlan, Ahmad Kartini,

Abstract

Murraya koenigii (Rutaceae), locally known as curry leaf tree, is a medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The bark of Malayan Murraya koenigii was investigated for phytochemical content. The isolation of chemical constituents from its hexane extract was carried out by using various chromatographic techniques. Spectroscopic methods, including NMR, IR, UV, MS spectra data, were used for the structural characterization. Four C23-carbazole alkaloids were isolated..

Article Published 2014 3561 hits Available

Isolation of aporphine alkaloid from the leaves of Alseodaphne corneri Kosterm

Khoo Jennie, Hui Chen, Ahmad Kartini, Hasnan Muhammad Hafiz Husna, Mohammad Siti Nor Fadzilah, Awang Khalijah, A. Hadi A. Hamid, Nafiah Mohd Azlan,

Abstract

A phytochemical study on the leaf extract of Alseodaphne corneri Kosterm involving extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectra (UV), infrared spectra (IR), nuclear magnetic resonance (NMR) and mass spectra (MS) was carried out. The isolation and purification from the leaves of Alseodaphne corneri Kosterm yielded two aporphines: norlirioferine and lirioferine...

Article Published 2014 7571 hits Available

Flavonoid from the Sao Pedro Petro of tubers of cassava (Manihot esculenta Crantz)

Mohamad Azlan Nafiah

Abstract

The flavonoid compound, quarcetin-3-O-rutinoside (1) has been isolated from n-BuOH extract of the fresh of Sao Pedro Petro of Tubers of Cassava (Manihot esculenta Crantz). The chemical structure of compound (1) was identified by spectroscopic data including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H1H COSY) and MS and by comparing with previously reported spectral data. ..

Article Published 2019 1811 hits Available

A leaf wax and small metabolites from the leaves of alphonsea cylindrica

Mohd Azlan Nafiah

Abstract

[No abstract available]..

Article Published 2023 901 hits Available

Phytochemical study of stem bark from Alstonia spathulata Bl. (Apocynaceae)

Tee Chuan Thing, Lee Yean Shan, Tan Siow Ping, Awang Khalijah, Nafiah Mohd Azlan, Ahmad Kartini,

Abstract

In Malaysia, Alstonia spathulata Bl. is locally known as ‘Pulai Basong’ which distribute in peat forest. The separation of the chemical components from hexane and DCM crude extract of Alstonia spathulata was carried out using column chromatography (CC) and thin layer chromatography (TCL) techniques. A total of five known compound were isolated from the stem bark extracts and identified as: β-amyrin, β-amyrin acetate, lupeol acetate, stigmasterol and β-sitosterol. The elucidation structures of these compounds were established using 1D-NMR (1H, 13C and DEPT) and 2D-NMR (COSY, HSQC, HMBC) spectroscopic analysis, involving also comparison with data from the literature...

Article Published 2014 4174 hits Available

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