AbstractDepression is more frequently experienced among medical students than in the general population. In addition, medical training seems to have a negative impact on students’ mental health. The main objective of this study was therefore to determine the effects of parental support, personality, and self-efficacy on depression among medical students. This study also sought to find out the effects of parental support and personality on self-efficacy. Participants were 1,029 first to fifth year medical students in seven universities in peninsular Malaysia. A set of questionnaires comprised of Career-Related Parent Support Scale, NEO Personality Inventory-Revised, College Self-Efficacy Scale, and Beck Depression Inventory were used to measure parental support, personality, self-efficacy and depression respectively. Results of multiple regression analysis showed that conscientiousness, extraversion and neuroticism predicted self-efficacy while self-efficacy, neuroticism, and conscientiousnes.....