A total of eleven ortho-carboxamidostilbene derivatives were synthesized through Heck coupling with a different type of amide derivatives. These compounds were characterized by FTIR, 1D-and 2D-NMR as well as mass spectroscopy analysis (HRESIMS). The synthesized compounds were tested for their cytotoxic potential against four human cancer cell lines (MCF-7, MDA-MB-231, MCF-7/TAMR-1, and A549), as well as two human normal cell lines (MCF-10A and BEAS-2B) using tamoxifen and cisplatin as a positive control. The active compound has proceeded with molecular docking on the colchicine binding site of tubulin protein using AutoDock Vi-na and Biovia Discovery Studio. Compounds 6a, 6d-6k exhibited selective cytotoxic activity against A549 cells rather than breast cancer cell lines. Compounds 6d, 6f, and 6g showed moderate cytotoxicity to A549 cells after 72 hours, with IC50 values of 10.4 M, 6.47 M, and 8.99 M, respectively. Interestingly, these compounds had a high selective index (SI) value ag.....

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Skills of reading and comprehending in English are crucial for academic success in schools. Pupils with low reading ability skill may result in obtaining low grades and poor test scores. Traditionally pupils are taught to lift specific information as a reading strategy to answer comprehension questions, comparatively, this study uses retelling strategy to evaluate pupils' understanding. Past research indicated that retelling strategy enhances accuracy and greater comprehension. Thus, far study that investigates effectiveness of this strategy remains scarce in Malaysian English as Second Language (ESL) primary schools. As reading skill starts to develop in early stage of schooling, it is deemed necessary to conduct this study among primary level pupils. The present study specifically analyzes the effects of written retelling strategy on pupils' understanding of story structure among year three primary school pupils in Malaysian ESL classroom. A quasiexperimental research design with pre.....

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Purpose: Ownership of insurance policy among Malaysians is growing, especially since the Covid-19 pandemic at the end of 2019. The aim of this study is to examine the effects of economic and non-economic factors that may contribute to incidence of failures in medical and health insurance claims. Research design, data and methodology: This study used primary data with samples collected in an online survey involving 210 respondents, in Perak State. By adopting the Howards-Sheth consumer behavior theory, the multiple binary logistic regressions were used. Results: The study established that income, saving and prior experience is the significant factors effecting the incidence of claim failures in at least 95 percent cases. This is supported by the Howards-Sheth consumer behavior theory. When the odds ratio value of income is at 47.84 percent, insurance claim will have less probability of success. At a certain income level, the probability of failure in insurance claim will be lower. Concl.....

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The primary objective of this article is to undertake a comprehensive and methodical examination of corpus-driven research endeavours carried out in the Asian region. A plethora of recent scholarly investigations have elucidated that the employment of corpus-driven methodologies across diverse fields and aims could derive advantageous outcomes through the utilisation of a diverse array of corpus linguistics software tools. The primary objective of corpus-driven analysis is to facilitate scholars in acquiring novel insights pertaining to a specific corpus, including the identification of pivotal keywords. The present investigation undertook a comprehensive examination of 21 scholarly research publications through the meticulous application of a systematic literature review methodology. The selection of Google Scholar and Scopus as the designated databases for the purpose of conducting a comprehensive search for pertinent scholarly resources has been made. A total of twelve research arti.....

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Sub-optimal learning outcomes have been observed, often attributed to monotonous educational processes that struggle to retain students' focus and stimulate active participation. This study investigates the potential influence of Augmented Reality (AR) on student motivation, utilizing a time series analysis approach. The primary objectives include assessing the impact of AR on student learning outcomes and identifying the most suitable model for elucidating this relationship. The central research question is: can the implementation of AR enhance student motivation in elementary education? A time series design with a quantitative methodology was employed, involving a cohort of 29 fourth-grade students in Indonesia. Data collection was conducted through a Likert scale questionnaire. Four trend models were tested: the Linear Trend Model, Quadratic Trend Model, Growth Curve Model, and S-Curve Trend Model. The analysis of the collected data, tabulated and analyzed based on the established t.....

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Malaysia is one of the vulnerable regions of cyberattack in which cybercrimes continue to increase at alarming rate. Cyber criminals are attacking not only organisations but also individuals. Various types of cybercrimes that have resulted in significant financial losses have been reported in the media. Despite the daily coverage of cybercrime incidents, people continue to fall victims. Keeping the public informed of the potential online threats should not be taken for granted. This study argues that effective communication of cybersecurity information is essential to enhance publics resilience in dealing with cybercrimes. Infographic is a useful tool for conveying cybersecurity information. Infographic is a visual communication that is often used to communicate complex messages that include science related information. Literature on infographics often emphasizes on its key components that include; visual, content and knowledge. As a visual form of communication, it makes information a.....

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This study aimed to develop an Android-based learning model for subjects of Creative Products and Entrepreneurship for catering students at Vocational Schools. The study analyzed the validity of Android- based learning models and analyzed practicality and the effectiveness of Android-based learning models for Creative Product and Entrepreneurship subjects for catering students at SMK Negeri 9 Padang. Based on the validity assessment of material experts, media experts, linguists, and practitioners, the average score of material aspects is 4.78 (Very Eligible), the media aspect is 4.22 (Very Eligible), and the language aspect is 4.23 (Very decent). The results of practicality tests for teachers and students, as well as the effectiveness test of the use of Android-based learning media on students of Creative Product and Entrepreneurship subjects conducted using a questionnaire, obtained a practicality value of 4.55 (feasible) and effectiveness of 4.62 (feasible). (2023) by the authors of.....

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Quality education is highly dependent on the level of professionalism of teachers and the effectiveness of educational leadership. Most studies related to educational leadership focus on the Principals and Headmasters, rather than examining the overall leadership including middle leaders who are the backbone of educational leadership. A more comprehensive study among education leaders is needed to further improve the quality of education in Malaysia. This study aimed to obtain expert consensus on the construct of professional leadership competencies for middle leaders in matriculation colleges using the Fuzzy Delphi Method. An instrument containing a list of elements of professional leadership competencies was presented to a total of 30 experts from various fields and background. The findings of this study indicate that the expert panel agreed on the constructs and elements of professional leadership competencies proposed. The threshold values of all 13 elements tested met the conditio.....

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The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo-intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o-cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 g/mL) and S. mutans (MIC 250 g/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 g/mL. The molecular docking study shows neo-intermedeol, eudesma-4,11-dien-3-one, ?-selinene, and ?-selinene as the good candidate to target Erg11 with a binding energy of ?7.3 kcal/mol. The.....

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Political cyber-troopers is a term that refers to activists paid to spread political propaganda in the media. The emergence of the cyber-troopers movement was seen to be significant in the 12th General Election and became more active in the 14th Election. In line with this development, the issue of political cyber-troopers began to gain the attention of scholars who studied its existence and role in the political context in Malaysia. However, studies on defining the term politics cyber-troopers are still limited. Thus, this term is equated with netizens and keyboard warriors. The lack of a suitable definition to describe cyber-troopers in Malaysia causes a negative stigma in the community. Therefore, this study analyses the definition and typology of political cyber-troopers in Malaysia using the conceptual framework of political astroturfing. This study uses qualitative methods through interview instruments with ten informants consisting of academics, cyber-troopers and political acti.....

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